ACS Chemical Biology Impact Factor, IF, number of article, detailed information and journal factor. Pharmaceutics, 2019, 16 (4), pp 1732–1741 Open Access Through ACS AuthorChoice ACS Med. Open Access Through ACS AuthorChoice These compounds are valuable tools to further investigate the therapeutic potential of aminoglycoside-induced PTCR. Perspectives on the potential transformation of CRO industry will contribute to the real-world practice and innovation of this business model. Chemical Reviews Impact Factor, IF, number of article, detailed information and journal factor. DOI: 10.1021/acsanm.9b00273, Fluorescent Fe3O4 Quantum Dots for H2O2 Detection Full Paper by Leon Wehrhan, Katharina Meier et al. These novel D1R agonists provide important tools to study D1R activation and signaling bias in both health and disease. Model., 2019, 59 (4), pp 1605–1623 Energy Mater., 2019, 2 (4), pp 2708–2716 Sci. OR SEARCH CITATIONS ... 2019; 2018; 2017; 2016; 2015; 2014; 2013; 2012; 2011; 2010; Partners 1155 Sixteenth Street N.W. Positive allosteric modulators (PAMs) of α7 nAChRs can have different properties with respect to their effects on channel kinetics. ACS Sustainable Chem. B, 2019, 123 (14), pp 3033–3042 Please accept the best wishes of our editorial teams for your ongoing health and wellbeing. Herein, we report the discovery and characterization of a novel potent and highly selective TBK1 inhibitor, GSK8612. Interfaces, 2019, 11 (14), pp 13039–13057 Org. Chem. ISSN: 0009-2665. Theory Comput., 2019, 15 (4), pp 2246–2253 Electron. Technol. 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Open Access Through ACS AuthorChoice DOI: 10.1021/acs.jpcb.8b12557, Atomic and Molecular Adsorption on Ag(111) Technol. Bisbenzyloxy can induce ER stress, and the N-(2-hydroxyethyl)formamide structure can increase the ratio of LC3II/I and cytoplasmic vacuolization and facilitates paraptosis. The acyl chain length was efficiently adjusted by an asymmetric alkyne–alkyne cross coupling strategy, and the newly synthesized α-GalCer analogues showed the high Th2-selective activity of iNKT cells. HLö-7 was visualized for the first time within the active site of human acetylcholinesterase and its relative ex vivo potency confirmed against various nerve agents using a phrenic nerve hemidiaphragm assay. Open Access Through ACS AuthorChoice J. Chem. Journal of Medicinal Chemistry Impact Factor, IF, number of article, detailed information and journal factor. DOI: 10.1021/acsami.9b00361, 3D Printing/Bioprinting Based Tailoring of in Vitro Tissue Models: Recent Advances and Challenges J. Med. Full Paper by Simon M. Ametamey, Yves P. Auberson et al. "The Division of Medicinal Chemistry and its members have been driving forces behind the discovery of revolutionary new medicinal agents and thus have had a major impact on human health. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our. Biol., 2019, 8 (4), pp 686–696 Chem. Open Access Through ACS AuthorChoice Data, 2019, 64 (4), pp 1826–1833 DOI: 10.1021/acsami.8b19067, Bioinspired Hairy Skin Electronics for Detecting the Direction and Incident Angle of Airflow However, no selective CDK5 inhibitor has been reported to date. ACS Energy Lett., 2019, 4 (4), pp 896–902 ACS Appl. DOI: 10.1021/acsapm.8b00138, Multiple Physical Cross-Linker Strategy To Achieve Mechanically Tough and Reversible Properties of Double-Network Hydrogels in Bulk and on Surfaces As this technology has evolved, the design of fragments for screening has also evolved to engender not just an understanding of the role of modulating the physicochemical properties of fragments (Rule of Three, Ro3) but also the importance and implications of incorporating shape and, in particular, 3D characteristics into fragments. Chem. J. Phys. A, 2019, 123 (13), pp 2559–2569 DOI: 10.1021/acsinfecdis.9b00080, Quantitative Lipid Droplet Proteomics Reveals Mycobacterium tuberculosis Induced Alterations in Macrophage Response to Infection Chem. 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DOI: 10.1021/acsbiomaterials.8b01337, Biomaterials and Bioengineering Approaches for Mitochondria and Nuclear Targeting Drug Delivery DOI: 10.1021/acscombsci.8b00179, Base Controlled Three-Component Regioselective Synthesis of 2-Imino Thiazolines and 2-Thioxoimidazolin-4-ones DOI: 10.1021/acs.energyfuels.8b03273, ES&T’s Best Papers of 2018 DOI: 10.1021/acs.estlett.9b00076, Editor’s Choice for the Best Papers Published in ES&T Letters in 2018 Chem. DOI: 10.1021/acs.jpclett.9b00512, A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation The nonpsychoactive phytocannabinoid, CBD, was recently approved by the Food and Drug Administration for the treatment of children with drug-resistant epilepsy. ACS Appl. Darapladib is one of the most potent Lp-PLA2 inhibitors with an IC50 of 0.25 nM. Chem. DOI: 10.1021/acs.iecr.8b05961, Comment on “Perturbed-Chain SAFT: An Equation of State Based on a Perturbation Theory for Chain Molecules” At 5 μM, the lead adjuvant, which is nontoxic to the bacteria alone, increases colistin efficacy 32-fold against bacteria containing the mcr-1 gene and effects a 1024-fold increase in colistin efficacy against bacteria harboring chromosomally encoded colistin resistance determinants; these combinations lower the colistin minimum inhibitory concentration (MIC) to or below clinical breakpoint levels (≤2 μg/mL). DOI: 10.1021/acsami.9b01753, Advanced Functional Fibrous Materials for Enhanced Thermoregulating Performance Dis., 2019, 5 (4), pp 559–569 Process Res. Inf. Chem. DOI: 10.1021/acssensors.9b00390, Challenges and Promises of Metal Oxide Nanosensors Eng., 2019, 7 (7), pp 6654–6661 Open Access Through ACS AuthorChoice Res. Learn about our remote access options, Editorial Board Chairs: Karl-Heinz Altmann, Sangyong Jon, Antonello Mai. Lett., 2019, 6 (4), pp 228–234 Mater., 2019, 1 (4), pp 804–814 About Organic Letters. You can look at citations, Altmetric Attention Scores, awards, and more. The journal publishes short articles ("letters") on experimental or theoretical results of exceptional timeliness in all aspects of pure and applied medicinal chemistry and its extension into pharmacology. Now more than ever, it is important to mention clearly which suggestions you consider to be essential.


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